Details of the Drug

General Information of Drug (ID: DM0P63W)

Drug Name

Guanidine Hydrochloride

Synonyms

Guanidine hydrochloride; 1950/1/1; Guanidinium chloride; Guanidine, monohydrochloride; guanidine HCl; Aminoformamidine hydrochloride; Aminomethanamidine hydrochloride; GUANIDINE MONOHYDROCHLORIDE; Guanidine chloride; Iminourea hydrochloride; Carbamidine hydrochloride; Guanidinium hydrochloride; Guanidine (hydrochloride); UNII-3YQC9ZY4YB; Guanidium chloride; USAF EK-749; Guanidine, hydrochloride (1:1); EINECS 200-002-3; 3YQC9ZY4YB; AI3-19014; MFCD00013026; Guanidine Hydrochloride, ULTROL& Grade; Guanidinehydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Muscle fatigue	FB32.5	Approved	[1]

Therapeutic Class

Neurology Agents

Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

#Ro5 Violations (Lipinski):
0

Molecular Weight

95.53

Topological Polar Surface Area

Not Available

Rotatable Bond Count

0

Hydrogen Bond Donor Count

4

Hydrogen Bond Acceptor Count

1

Chemical Identifiers

Formula: CH6ClN3
IUPAC Name: guanidine;hydrochloride
Canonical SMILES: C(=N)(N)N.Cl
InChI: InChI=1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
InChIKey: PJJJBBJSCAKJQF-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 5742
ChEBI ID: CHEBI:32735
CAS Number: 50-01-1
TTD ID: D0F7NZ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor Alpha-2 (ADRA2)	TTQ8AFT	NOUNIPROTAC	Modulator	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Guanidine-based 2-adrenoceptor ligands: Towards selective antagonist activity.Eur J Med Chem.2014 Jul 23;82:242-54.
3	Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats. Pharmacol Biochem Behav. 2000 Nov;67(3):397-403.
4	Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor ... Eur J Pharmacol. 2008 Mar 17;582(1-3):70-7.
5	Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis. Am J DrugAlcohol Abuse. 2008;34(5):611-6.
6	Emerging drugs for attention-deficit/hyperactivity disorder. Expert Opin Emerg Drugs. 2007 Sep;12(3):423-34.
7	Dexmedetomidine in intensive care unit: a study of hemodynamic changes. Middle East J Anesthesiol. 2002 Oct;16(6):587-95.
8	Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol (Phila). 2009 Sep;47(8):827-9.
9	Centrally acting sympathetic inhibitors for therapy of patients with hypertension. Nippon Rinsho. 1997 Aug;55(8):2081-5.
10	Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. Drugs. 1997 Mar;53(3):435-52.
11	Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries. Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2049-55.